Inwardly rectifying potassium channels
نویسندگان
چکیده
منابع مشابه
Inwardly rectifying potassium channels in Drosophila.
Inwardly rectifying potassium channels (Kir) are a special subset of potassium selective ion channels which pass potassium more easily into rather than out of the cell. These channels mediate a variety of cellular functions, including control of membrane resting potential, maintenance of potassium homeostasis and regulation of cellular metabolism. Given the existence of fifteen Kir genes in mam...
متن کاملInwardly rectifying potassium channels: their structure, function, and physiological roles.
Inwardly rectifying K(+) (Kir) channels allow K(+) to move more easily into rather than out of the cell. They have diverse physiological functions depending on their type and their location. There are seven Kir channel subfamilies that can be classified into four functional groups: classical Kir channels (Kir2.x) are constitutively active, G protein-gated Kir channels (Kir3.x) are regulated by ...
متن کاملRegions Responsible for the Assembly of Inwardly Rectifying Potassium Channels
Inwardly rectifying potassium channels have an important role in determining the resting potential of the cell. They are tetrameric proteins with two transmembrane segments (M1 and M2), a pore-forming loop (H5), a cytoplasmic N-terminal, and longer C-terminal domain. We have used biochemical and electrophysiological methods to identify regions required for homotypic interactions and those respo...
متن کاملG-protein mediated trafficking of inwardly rectifying potassium channels
Kir2 potassium channels help control the resting membrane potential and shape the action potential in cardiac cells. Changes in Kir2 trafficking have been linked to Andersen’s Syndrome, a disorder characterized by cardiac arrhythmias. Here, we investigated the role of Rac1, a small GTPase, on Kir2.1 channels expressed in mammalian tsA201 cells. Expression of the dominant-negative form of Rac1 (...
متن کاملDifferential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.
Recent studies have shown that Kir2 channels display differential sensitivity to intracellular polyamines, and have raised a number of questions about several properties of inward rectification important to the understanding of their physiological roles. In this study, we have carried out a detailed characterization of steady-state and kinetic properties of block of Kir2.1-3 channels by spermin...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2005
ISSN: 0108-7673
DOI: 10.1107/s0108767305090136